| Dean Winchester | Touchi Hiroki |
| Dean Winchester (Boyhood) | Abe Atsushi |
| Samuel "Sam" Winchester | Uchida Yuuya |
| Samuel "Sam" Winchester (Boyhood) | Tsumura Makoto |
| John Winchester | Hashi Takaya |
| Mary Winchester | Andou Mabuki |
| Jessica Moore | Sonozaki Mie |
| Bobby Singer | Taniguchi Takashi |
| Missouri Moseley | Tamura Seiko |
| Meg Masters | Mizuki Nana |
| Azazel | Uchida Naoya |
| Mysterious Beautiful Woman | Sakakibara Yoshiko |
| Jake | Miki Shinichirou |
| Katherine Boyle (ep.1) | Neya Michiko |
| Zach Evans (ep.1) | Yasui Kunihiko |
| Amanda Evans (ep.1) | Ukai Rumiko |
| Molly (ep.2) | Hikami Kyoko |
| David (ep.2) | Nakahara Shigeru |
| Jonah Greeley (ep.2) | Kanemitsu Nobuaki |
| Marion Greeley (ep.2) | Taki Kahoko |
| Jenny (ep.3) | Shinohara Emi |
| Sarie (ep.3) | Horanai Ai |
| Ritchie (ep.3) | Miyagawa Miho |
| Police Chief Rod (ep.4) | Aizawa Masaki |
| Deputy Police Chief Michael (ep.4) | Inoue Norihiro |
| Ryan (ep.5,14) | Namikawa Daisuke |
| Jason (ep.5) | Arimoto Kinryuu |
| Gale (ep.5,14) | Nishimura Tomomichi |
| Miranda (ep.5) | Nagaki Kiyoko |
| Charlie (ep.5) | Morita Masakazu |
| Lisa (ep.6) | Watanabe Akeno |
| Maria Masters (ep.7) | Tsuda Shouko |
| Richard Sullivan (ep.8) | Hori Katsunosuke |
| Abigail Sullivan (ep.8) | Hidaka Noriko |
| Police Inspector Sanchez (ep.8) | Houki Katsuhisa |
| Nancy (ep.8) | Kawaragi Shiho |
| Katty (ep.9) | Yamagata Kaori |
| Adolf (ep.9) | Sugou Takayuki |
| Orlan (ep.9) | Nakagi Ryuuji |
| God of Poverty (ep.9) | Asou Tomohisa |
| Madison (ep.10) | Kuwashima Houko |
| Max Miller (ep.11) | Yoshino Hiroyuki |
| Jim Miller (ep.11) | Tanaka Masahiko |
| Mrs. Miller (ep.11) | Ishizuka Rie |
| Lily Baker (ep.12) | Noto Mamiko |
| Gray Baker (ep.12) | Yanaka Hiroshi |
| Gray's Wife (ep.12) | Takeda Hana |
| Ed (ep.13) | Kiyokawa Motomu |
| Steve (ep.13) | Inaba Minoru |
| Kim (ep.13) | Kano Yui |
| Eric (ep.13) | Hanawa Eiji |
| Tessa (ep.16) | Endou Aya |
| Lyle (ep.17) | Park Romi |
| Anderson (ep.17) | Sawaki Ikuya |
| Evan (ep.18) | Tanaka Hideyuki |
| Crossroads Demon (ep.18) | Katsuki Masako |
| Ted (ep.18) | Tobita Nobuo |
| Tyron (ep.19) | Morikawa Toshiyuki |
| Danny (ep.19) | Sakaguchi Daisuke |
| Debora (ep.19) | Satou Ai |
| Lynn (ep.19) | Takaguchi Yukiko |
| Carmen (ep.20) | Matsui Naoko |
| Ava (ep.21) | Okamura Akemi |
| Andy (ep.21) | GACKT |
